Don't Suffer With Peyronie's Disease. We Have Solutions

 Peyronie's disease, a condition in which the penis becomes curved, can be painful, cause erectile dysfunction, and make you feel alone. However, this disease affects at least 1 out of every 100 men in the United States. That number is likely much higher, as many men are embarrassed to seek help and are therefore not formally diagnosed.  

This is unfortunate because help exists.  Board Certified Urologist Dr. T. Mike Hsieh, located in La Jolla, CA, has helped many patients with Peyronie’s disease reclaim their health and sex lives without surgery. 

Here he explains everything you need to know about Peyronie’s disease and the help that’s available.

What is Peyronie’s disease?

Peyronie’s disease, characterized by a curvature of the penis, emerges due to the formation of fibrous scar tissue. Penises naturally differ in shape and size; a curved erection is not always cause for concern. However, when the cause is Peyronie's disease, some men experience a pronounced bend in the penis accompanied by pain.

This can significantly impact sexual function, potentially causing difficulties in achieving or sustaining an erection. Men with Peyronie's disease may also experience heightened stress and anxiety about potential penile shortening.

Peyronie's disease rarely resolves on its own and often worsens over time. 

What non-surgical treatment exists for Peyronie’s disease?

In most cases, Dr. Hsieh can resolve Peyronie’s disease symptoms without surgery. 

During the acute phase, he may administer medications directly into the plaques through intralesional injections. Before the injection, the injection site is anesthetized for patient comfort. Injection options include:

Collagenase (Xiaflex)

The only FDA-approved treatment for Peyronie's disease, intralesional collagenase injections, known as Xiaflex, consists of an enzyme that helps break down the plaque. The process reduces penile curvature and enhances erectile function. It’s recommended for individuals with penile curvature exceeding 30 degrees.


Initially used to manage high blood pressure, Verapamil may alleviate penile pain and curvature when injected into the plaque.

Interferon-alpha 2b

Derived from white blood cells, Interferon-alpha 2b can reduce pain, penile curvature, and plaque size.

Oral Medications

Potassium para-aminobenzoate, primarily used for Dupuytren's contracture, might help reduce plaque size, though not correct penile curvature.

If you are in pain, Dr. Hsieh may recommend nonsteroidal anti-inflammatory drugs (NSAIDs).

Surgical intervention

Only when nonsurgical interventions are unsuccessful is surgery considered. Several surgery options exist, which Dr. Hsieh will discuss if necessary.

Don't suffer in silence if you suspect you have Peyronie’s disease. Seek help. Call Dr. Hsieh’s office in La Jolla, CA, or reach out online.

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